RNA Transfection Kit for Stem Cells
Satreda LNP8008
Empowering the Future of Regenerative Medicine
By combining high payload capacity, efficient delivery, low toxicity, and broad applicability, the Satreda LNP8008 kit empowers researchers to unlock the full potential of RNA-based applications in stem cell biology, regenerative medicine, and advanced therapeutic development.
A Breakthrough for Stem Cell Research
The Satreda LNP8008 kit is a groundbreaking solution specifically designed to address one of the biggest challenges in modern molecular biology — the efficient and safe transfection of stem cells. Leveraging Satreda’s proprietary advanced lipid material platform, this kit brings the precision and efficiency of cutting-edge lipid nanoparticle (LNP) technology to stem cell research, enabling applications that were previously limited by low transfection efficiency and high cytotoxicity.
Overcoming Stem Cell Transfection Barriers
Stem cells, such as mesenchymal stem cells (MSCs), are notoriously difficult to transfect due to their fragile nature and distinct biological properties. LNP8008 overcomes these barriers by employing novel, biodegradable ionizable lipids that deliver high RNA payloads with minimal cytotoxicity, ensuring that cell viability and stem cell integrity are maintained throughout the process.
Broad RNA Compatibility for Diverse Applications
With its broad RNA compatibility, LNP8008 supports the efficient encapsulation and delivery of diverse nucleic acid types, including siRNA, miRNA, gRNA, mRNA, saRNA, and circRNA. This versatility allows researchers to tailor experiments for a wide range of applications, such as:
mRNA-based reprogramming factor delivery for safe and non-integrating stem cell reprogramming.
siRNA-mediated modulation of differentiation pathways, giving researchers powerful tools to study lineage specification and regenerative medicine applications.
Co-transfection workflows, enabling synergistic delivery of multiple RNA types in a single experiment.
Ready-to-Use Simplicity and Safety
One of the standout advantages of LNP8008 is its ready-to-use, ethanol-free formulation, which ensures safety, consistency, and ease of use. Unlike traditional methods that can take many hours or even days for RNA encapsulation, the Satreda LNP system allows RNA encapsulation within just one minute, dramatically streamlining experimental workflows while delivering superior results.
Validated Stem Cell Performance
In validated case studies, human umbilical cord-derived MSCs transfected with LNP8008 demonstrated robust eGFP mRNA expression using recommended doses as low as 1.25 µL per well in serum-free medium. These results highlight the kit’s ability to maintain both high transfection efficiency and low cytotoxicity, setting a new benchmark for stem cell RNA delivery.
